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KMID : 1190620160120020046
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Journal of the Korean Wound Care Society
2016 Volume.12 No. 2 p.46 ~ p.50
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3D Cell-printing of Skin: A State-of-the-art Review
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Kim Byoung-Soo
Yi Hee-Gyeong
Park Ju-Young
Choi Yeong-Jin
Cho Dong-Woo
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Abstract
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Beyond the use of skin grafts for wound management, in vitro human skin tissue models have been used for various biomedical and cosmetic applications. In particular, a complete ban on animal testing for cosmetics by the European Union (EU) indicates the need for the development of more biomimetic human skin models that recapitulate complicated microenvironments of native skin. However, current in vitro skin models are still far from ideal in terms of pigmentation, vascularization, and hair follicles due to the reliance on manual fabrication methods. Three-dimensional (3D) cell-printing technology provides a fully automated platform that allows for the highly organized deposition of multiple types of skin cells and biomaterials, which would be hardly realized by the conventional skin tissue engineering approaches. It is obvious that this technique enables us to develop full functional skin models in the future. Here, we provide a current overview of 3D cell-printing of skin. First of all, 3D cell-printing techniques are presented based on working principles: inkjet-based, extrusion-based, and laser-assisted methods. We further present the reported works on skin printing, and share the future directions of the field, followed by conclusions.
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KEYWORD
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Skin grafts, Human skin tissue models, Three-dimensional (3D) cell printing, Conventional skin tissue engineering approaches
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